Alexandre Amlie-Wolf

About Me

I'm Alex, a Ph.D. candidate since the fall of 2013 in the Genomics and Computational Biology program at the University of Pennsylvania Perelman School of Medicine in Li-San Wang's lab, part of the department of Pathology and Laboratory Medicine. My research is focused on understanding how noncoding genetic variants regulate gene expression and modulate disease risk. To do this, I develop algorithms to annotate genetic variants with regulatory activity, unbiasedly identifying the regulatory mechanisms affected by noncoding genetic variants, the target genes and relevant tissue contexts of those regulatory mechanisms, and the downstream biological processes modulating disease risk. These bioinformatics methods are trait-agnostic, but my research mainly focuses on neurodegenerative diseases and psychiatric traits.